akkermansia muciniphila probiotic benefits

In vitro, Akk treatment increases anti-inflammatory cytokines and the expression of tight junctional integrity markers but reduces gingipain mRNA expression, which is associated with an increased expression of Akk and pili-like protein Amuc_1100 [114]. Plovier H., Everard A., Druart C., Depommier C., Van Hul M., Geurts L., Chilloux J., Ottman N., Duparc T., Lichtenstein L., et al. Akkermansia muciniphila as a Next-Generation Probiotic in Modulating A high-fat, high-cholesterol (HFHC) diet usually leads to early NASH in rats with gut microbiota dysbiosis and microbial metabolite alterations, which are accompanied by cognitive impairment [81]. Akk can increase thermogenesis by interacting with ICAM-2 and its secreted P9 protein stimulates L cells to secrete GLP-1, which maintain glucose homeostasis mediated by IL-6. 2017 Dec;31(6):637-642. doi: 10.1016/j.bpg.2017.10.001. Probiotics refer to live microorganisms which when intake in adequate amounts can benefit on host health as regulated by the FAO/WHO [2,3]. Finally, these bile acids induce transmembrane G-protein coupled receptor-5-dependent anti-inflammatory responses to mitigate SFTSV infection [113]. Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. I always say, when it comes to your health, you are your own best advocate. Ercc1/7mice treatment with Akk prevents the aging-related decline in the thickness of the colonic mucus layer and attenuates inflammation and the immune-related process by affecting B cell migration to increase mature and immature B cell frequencies in the bone marrow [16]. mBio, 8(5), e00770-17. This research also uncovers the bone-protective benefit of EVs derived from alive Akk in Ovx-induced bone loss model mice that does not include pasteurized Akk. T2D, overweightness, obesity, and long-term alcohol consumption generally accompanied by and/or leading to NAFLD/ALD, which include simple steatosis, fibrosis, and cirrhosis, all of which can deteriorate towards ASH/NASH and ultimately deteriorate to HCC. One way in which spore-forming probiotics accomplish this, is by supporting and promoting a healthy population of akkermansia muciniphila. So far, research has associated this with a lower risk for diabetes, Irritable Bowel Syndrome (IBS), metabolic syndrome, obesity, and even cancer. But when it comes to supplements, not all brands are created equally. These nanovesicles can enter and accumulate in bone tissues to attenuate an ovx-induced osteoporotic phenotype by augmenting osteogenic activity and inhibiting osteoclast formation [42]. Yet, some of the above reports also imply that Akk may interact with some specific microbes or be affected by the host gut microenvironment, which means we must be cautious about its application in clinical cancer treatment. Li J., Lin S., Vanhoutte P.M., Woo C.W., Xu A. Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice. Depommier C., Everard A., Druart C., Plovier H., Van Hul M., Vieira-Silva S., Falony G., Raes J., Maiter D., Delzenne N.M., et al. Pierre, J. F., Heneghan, A. F., Feliciano, R. P., Shanmuganayagam, D., Roenneburg, D. A., Krueger, C. G., Reed, J. D., & Kudsk, K. A. Epub 2019 Apr 21. Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis. Akkermansia Muciniphila: The Most Powerful Probiotic Youve Never Heard Of. (A) Long-term HFD/HFHC diets usually result in neurodegenerative diseases such as cognitive impairment, impaired spatial working memory and novel object recognition, and damaged brain metabolism in early life, while supplementation with Akk can prevent it. Akkermansia muciniphila comprises 1-3% of the bacteria in the gut and is considered a keystone strain. (E) The forms of Akk and its outer membrane components. Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. Current barriers in terms of regulations, necessity for large-scale clinical experiments and production feasibility need to be resolved before A. muciniphila can be widely applied as the next-generation probiotic. In vivo, bacterial cross-feeding decreases gamma-glutamyltranspeptidase activity and inhibits gamma-glutamylation to promote the seizure protection function [154]. 1 ). Microb Biotechnol. (12), In addition to supplementing with Akkermansia directly, several studies have found that polyphenol-rich supplements such as cranberry extract can also increase Akkermansia levels in the gut. FMT and co-housing experiments reveal that predisposing gut microbiota is required for the enhanced susceptibility to colitis of TLR4/ mice, and TLR4 knockout suppresses RORt+ Treg cells to exacerbate colitis in a gut-microbiota-dependent manner; additionally, colonic RORt+ Treg cell frequency is negatively correlated with colitis severity [108]. Treatment with Akk ameliorates cognitive deficits and amyloid pathology by improving glucose tolerance, intestine barrier dysfunction, dyslipidemia, and pathological changes in the brain and relieving the impairment of spatial learning and memory in AD model mice induced by HFD [150]. The gut microbiota plays a critical role in IBDs pathogenesis, progression, and disease severity and is relevant to mucosal immunity and host metabolism [96,97]. Probiotics in FoodHealth and Nutritional Properties and Guidelines for Evaluation. On the one hand, the beneficial impact of Akk on certain kinds of diseases is still emerging, including obesity, diabetes, metabolic syndrome, aging, inflammation, neurodegenerative diseases, cancer, and so on. Similarly, EVs are required for the gut microbiotas of children and to cause the Akk-induced bone protective effect [42]. Received 2023 Jan 14; Revised 2023 Feb 9; Accepted 2023 Feb 12. The fecal microbiome of ALS patients. An obesity-associated gut microbiome with increased capacity for energy harvest. Hall K.E., Proctor D.D., Fisher L., Rose S. American gastroenterological association future trends committee report: Effects of aging of the population on gastroenterology practice, education, and research. Akk affects cancer therapy efficacy in multiple cancers. These reports indicate that Akk can ameliorate T1D by activating the immune response and recovering gut microbiota homeostasis. Fecal microRNAs (miRNAs) participate in shaping the host gut microbiome, and oral administration of microRNA-30d-5p (miR-30d) from the feces of patients with MS can suppress MS-like symptoms in mice by increasing Akk abundance [145,149]. Dr. Jill is Your Functional Medicine Expert! I recommend MegaPrebiotic a prebiotic clinically proven to support a diverse microbiome and selectively feed keystone bacteria like akkermansia muciniphila. As one of the next-generation probiotic candidates, Akkermansia muciniphila (A. muciniphila) has been discovered to enhance the gut barrier function and moderate inflammatory responses, exhibit improved effects with pasteurization and display beneficial probiotic effects in individuals with obesity, type 2 diabetes, atherosclerosis and autism . Akkermansia muciniphila and Helicobacter typhlonius modulate intestinal tumor development in mice. Qin J., Li Y., Cai Z., Li S., Zhu J., Zhang F., Liang S., Zhang W., Guan Y., Shen D., et al. FMT from the KD gut microbiota and treatment with Akk and Parabacteroides each confer seizure protection to mice fed a control diet, this being associated with alterations in colonic lumen, serum, and hippocampal metabolomic profiles correlated with seizure protection, including reduction in systemic gamma-glutamylated amino acids and elevation of hippocampal GABA/glutamate levels [154]. Food and Agriculture Organization of the United Nations. 2020 The Society for Applied Microbiology. Clipboard, Search History, and several other advanced features are temporarily unavailable. A Critical Perspective on the Supplementation of Akkermansia The above two clinical trials indicate that short-term (three months) oral administration of alive or pasteurized Akk is safe, which provides a reference for the clinical application of Akk in human anti-obesity treatment, although we still need more clinical investigations to evaluate the long-term safety of Akk in humans (Figure 1). World Health Organization . Thornton D.J., Sheehan J.K. From mucins to mucus: Toward a more coherent understanding of this essential barrier. van der Lugt B., van Beek A.A., Aalvink S., Meijer B., Sovran B., Vermeij W.P., Brandt R.M.C., de Vos W.M., Savelkoul H.F.J., Steegenga W.T., et al. Science 338, 120-123. Bian X., Wu W., Yang L., Lv L., Wang Q., Li Y., Ye J., Fang D., Wu J., Jiang X., et al. The treatment of mice with Akk for 4 weeks significantly accelerated the proliferation of Lgr5+ intestinal stem cells (ISCs) mediated by Wnt signaling and promoted the differentiation of Paneth cells and goblet cells in the small intestine (SI) and colon, which was further evidenced by SI organoids cultured with cecal contents obtained from Akk-treated mice being larger and dependent on GPR41/43 [165]. For instance, Akk and Helicobacter typhlonius double colonization significantly reduces the number of intestinal tumors, the mucus layer thickness, and goblet cell density of Fabpl Cre; Apc15lox/+ mice. do not necessarily reflect the official policy or position of the host. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. The genotype of Akk also differentially affects brown adipose tissue inflammation and whitening in HFD-fed mice [43]. Towards metabolic biomarkers of insulin resistance and type 2 diabetes: Progress from the metabolome. Atherosclerosis (AS) is the main contributor to cardiovascular mortality [83]. Oral drugs for treating obesity and associated metabolic diseases prevent the development of NFALD by increasing the abundance of Akk, for instance, Bofutsushosan [77,78], Fucoidan [79], and Liraglutide [80]. Akk treatment also promotes SCFA secretion and ISC-mediated epithelial development, as well as changing the composition of the gut microbiota and SCFA production, which was evidenced in germ-free mice [165]. Ouyang J., Lin J., Isnard S., Fombuena B., Peng X., Marette A., Routy B., Messaoudene M., Chen Y., Routy J.-P. A recent review elaborated on Akk as a sentinel for gut permeability and its relevance to HIV-related inflammation, and the author suggested that gut microbiota enriched in Akk could reduce microbial translocation and inflammation, lower the risk of developing non-AIDS comorbidities, and improve quality of life in people living with HIV (PLWH) [112]. , Axling, U. , Xu, J. , Sward, K. , Ahrne, S. , Molin, G. , et al (2013) Diverse effects of oats on cholesterol metabolism in C57BL/6 mice correlate with expression of hepatic bile acidproducing enzymes. Epub 2022 Nov 28. Antibiotic treatment or germ-free rearing depletes the KD-mediated seizure protection function in mice, whereas enrichment of, and gnotobiotic co-colonization with, KD-associated Akk and Parabacteroides restores seizure protection [154]. The A. muciniphila strain was isolated, MeSH It naturally eats up old mucus, producing valuable byproducts our body uses, and sets the stage for the gut to add new, fresh mucus. However, the differentiation of Tregs and the production of short-chain fatty acids (SCFAs) of strain ATCC BAA-835T was stronger than strain 139, although both of them facilitated the normalization of the gut microbiota in DSS mice [26]. Nowadays, the mucin medium is widely and mainly used to cultivate Akk, but the risk of animal-derived mucins is incompatible with human administration. Its key to immune system function and its presence (or lack thereof) may be able to predict the presence of disease.Akkermansia muciniphila was first discovered in 2004 in human stool. Yep, its a mouthful. Allobaculum isolates from patients with UC exacerbate mouse colitis, and it is inversely associated with Akk in human-microbiota-associated mice and human cohorts [107]. The https:// ensures that you are connecting to the It supports brain health, gut health, and liver function and can help your Akkermansia muciniphila grow and thrive.Nourish Your Akkermansia with Balance Oil, Geerlings, S. Y., Kostopoulos, I., de Vos, W. M., & Belzer, C. (2018). An official website of the United States government. Xie J., Li H., Zhang X., Yang T., Yue M., Zhang Y., Chen S., Cui N., Yuan C., Li J., et al. Large-scale population genomics analyses of the Akk genus in humans and other animals uncovered a large phylogenetic and functional diversity of the Akk genus in humans [31]. Compared with Akk, EVs derived from Akk induce a more significant loss in body and fat weight in HFD-fed mice [39]. Key Points The recent discovery of Akkermansia muciniphila is a scientific breakthrough. Differently from Europeans, the healthy Chinese population has a low presence of intestinal Akk, and patients with CD and UC have significantly lower colonization and abundance of Akk [105]. Akkermansia muciniphila; biomarker; health benefit; host physiology; probiotic. Click here to learn more about Pendulums unique supplements and order yours today. Its speculated to protect against illness. And, its much more likely to be present in healthy guts (and deficient in unhealthy guts).Read on to learn why. Akkermansia Muciniphila: How This Powerful Probiotic Can Boost Your MegaPrebiotic is made from corn and milk. As such, Akkermansia may help to maintain gut barrier function, immune balance, inflammation, metabolism, brain health, and more (3; 4; 5).Due to its benefits for blood sugar regulation, and specifically GLP-1 production, it may help work alongside other probiotics to reduce blood sugar spikes by 33% in type 2 diabetics in response to a high-sugar meal (6). Max: 28.6% Percentage of samples in which: present: 82% absent: 18% Yes, that median value is correct! Hnninen A., Toivonen R., Pysti S., Belzer C., Plovier H., Ouwerkerk J.P., Emani R., Cani P.D., De Vos W.M. Review hails Akkermansia as "most promising next-gen probiotic" Ouwerkerk J.P., Aalvink S., Belzer C., de Vos W.M. So how exactly do probiotics like akkermansia muciniphila impact your metabolism and overall metabolic health? Chow-fed mice treated with LPS mimicked HFD-induced hippocampus-dependent cognitive impairment, while pharmacological blockade of TLR4 signaling or antibiotics treatment effectively prevented hippocampus-dependent learning and memory deficits in HFD-fed mice [53]. Metabolic syndromes include ALD, NAFLD, NASH, neurodegenerative diseases induced by diets such as HFD/HFHC, and atherosclerosis, and have become one of the major challenges of diseases affecting global public health. In vitro, EVs ameliorate gut permeability by interacting with TLR2 and TLR4 and increasing the expression of TJ proteins in Caco-2 cells [37,48]. Crit Rev Food Sci Nutr. Similarly, Apoe/ mice fed with WD also indicated aggravated development of atherosclerotic lesions that was accompanied by reduction in Akk [85]. In this enlightening interview, Dr. Jill Carnahan sits down with the renowned functional medicine practitioner, Dr. Izabella Wentz, to discuss the Adrenal Transformation Protocol. Compared with lard, mice fed fish oil for 11 weeks (dietary lipid-enriched omega-3 polyunsaturated fatty acid) demonstrated significantly increased abundance of Akk and Lactobacillus in their cecal contents [184]. Akk also decreases the frequency of activated CD80+CD273-B cells in Peyers patches and Ly6Cint monocyte frequencies in the spleen and MLNs but increases the number of peritoneal resident macrophages [16]. Cross-talk between Akkermansia muciniphila and multiple gut organs alleviates obesity and diabetes. Yep, this incredible recycling system is working inside your gut without a bit of your conscious effort. Arthur, J.C., Perez-Chanona, E., Marcus, M., Tomkovich, S., Uronis, J.M., Fan, T.J., Campbell, B.J., Abujamel, T. et al. In obese and T2D mice, Akk abundance is significantly decreased and feeding prebiotics can normalize the abundance of Akk, which is correlated with an improved metabolic profile [47]. Probiotic interventions have been extensively used with controversial benefits in humans. However, most of the current researches focus on the correlation between A. muciniphila and diseases, and little is known about the causal relationship between them. Curr Microbiol. Turner M.R., Hardiman O., Benatar M., Brooks B.R., Chio A., de Carvalho M., Ince P.G., Lin C., Miller R.G., Mitsumoto H., et al. Akk exacerbates the inflammatory response caused by murine Salmonella enterica Typhimurium and DSS. Intense Brain Fog and Relentless Fatigue in POTS: How Can We Treat It? Accessibility The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). This study illustrates that consumption of the particular probiotic strain B420 has a novel role in modifying the microbiome in addition to supporting weight management. The biological function diversity mediated by genome, genotype, and strain source difference of Akk still needs further investigation before it can enter clinical application due to this question rarely being elaborated on. Compared with placebo individuals, overweight or obese subjects administered alive and pasteurized Akk modulated amino acid metabolism by reducing their levels of arginine and alanine and several intermediates of tyrosine, phenylalanine, tryptophan, and glutathione metabolism [50]. Akkermansia muciniphila is an extremely unique probiotic that makes its home in your gut. Keywords: Things like inflammation, leaky gut, insulin resistance, and recurring infections could mean it's time to encourage your gut lining to regenerate.Unfortunately, there arent a lot of foods that directly contain Akkermansia muciniphila and fiber isnt as powerful of a solution as it is with other probiotics. Akk and its metabolite propionate produced by co-cultivated Akk and organoids affect cellular lipid metabolism by modulating the expressions of fasting-induced adipose factor (FIAF), G protein-coupled receptor 43 (GPR43), histone deacetylase (HDACs), and peroxisome proliferator-activated receptor gamma (PPAR) [51]. Li S., Wang N., Tan H.-Y., Chueng F., Zhang Z.-J., Yuen M.-F., Feng Y. Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease. Information about supplements is always based on ingredients. Xing J., Li X., Sun Y., Zhao J., Miao S., Xiong Q., Zhang Y., Zhang G. Comparative genomic and functional analysis of Akkermansia muciniphila and closely related species. This handcrafted and researched bundle includes all of the crucial pieces you need to release and flush out toxins in 30 days. The abundance of Akk is significantly decreased in patients with CD with disease onset below 16 years of age, but there is no difference across different disease states such as healthy controls, UC, IBS, and colorectal cancer (CRC), which implies Akk may be a potential biomarker to assist in pediatric CD diagnosis [98]. Inflammatory bowel diseases (IBDs), including Crohns disease (CD) and ulcerative colitis (UC) [91], irritated bowel syndrome (IBS) [92], colitis [26], obesity- and diabetes-associated chronic inflammation [93], osteoarthritis (OA) [94], and arthritis [95] are the main types of chronic inflammation. Direct replenishment of Akk is sufficient to prevent Ovx-induced imbalanced bone metabolism and protect against osteoporosis via promoting the secretion of EVs, and this is required to induce child gut microbiota- and Akk-induced bone-protective effects [42]. Strategies to promote abundance of Akkermansia muciniphila , an In ethanol feeding of wild-type mice, Akk abundance is decreased, but administration of Akk reverses intestinal Akk depletion induced by ethanol and ameliorates hepatic injury, steatosis, and neutrophil infiltration [71]. eCollection 2023. A well-maintained home and lawn are less likely to attract unwanted bugs, weeds, and critters.Due to limited diet diversity, and dropping microbiome diversity A. muciniphila is often deficient in those with inflammation and immune imbalances.Two metabolites include short-chain fatty acids such as propionate and acetate, that support the health of other beneficial bacteria leading to increases in butyrate.Animal study shows that specialized cells responsible for mucus production are increased with A. muciniphila supplementation (2).
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