In the absence of evidence to the contrary, it is prudent to assume that this finding is potentially qualitatively relevant to man.. Elfil M, Kamel S, Kandil M, Koo BB, Schaefer SM. 1, pp. A key strategy was the engagement of scientists outside the company who could write papers that supported Syngentas defense of paraquat. Arch Neurol. Journal of Parkinson's Disease - Volume 11, issue s1 Interest/demand of researchers/scientists for publishing in a specific journal/conference. Federal government websites often end in .gov or .mil. In a 2021 peer-reviewed article, Dr. Douglas Weed, a physician and epidemiologist with over 25 years of experience in epidemiological research with no ties to Syngenta, concluded following a review of the scientific literature, No author of any published review stated that it has been established that exposure to paraquat causes Parkinsons disease, regardless of methods used and independent of funding source. As such, he determined that a consensus exists in the scientific community that the available evidence does not warrant a claim that paraquat causes Parkinsons disease.. Today it is well-established that the vast majority of Parkinsons cases are not caused by genetics, and that environmental factors, including air pollution and pesticides, play an important role. Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, Tan M, Kia DA, Noyce AJ, Xue A, Bras J, Young E, von Coelln R, Simn-Snchez J, Schulte C, Sharma M, Krohn L, Pihlstrm L, Siitonen A, Iwaki H, Leonard H, Faghri F, Gibbs JR, Hernandez DG, Scholz SW, Botia JA, Martinez M, Corvol JC, Lesage S, Jankovic J, Shulman LM, Sutherland M, Tienari P, Majamaa K, Toft M, Andreassen OA, Bangale T, Brice A, Yang J, Gan-Or Z, Gasser T, Heutink P, Shulman JM, Wood NW, Hinds DA, Hardy JA, Morris HR, Gratten J, Visscher PM, Graham RR, Singleton AB (2019) Identification of novel risk loci, causal insights, and heritable risk for Parkinsons disease: A meta-analysis of genome-wide association studies. * Required. Considering the devastating symptoms, high prevalence, and lack of definitive diagnostic test, there is an urgent need to identify possible biomarkers and new therapeutic targets. Similar strategies have been pursued by other chemical companies and in other industries when safety questions arose about profitable products. NEAT1 on the Field of Parkinsons Disease: Offense, Defense, or a Player on the Bench? Journal of Parkinson's Disease is published by IOS Press BV. Eradication of Helicobacter should be considered in patients with poor symptomatic control and considerable motor fluctuations. Searching for just a few words should be enough to get started. Additional evidence for mitochondrial dysfunction stems from models of autosomal-dominant PD due to mutations in alpha-synuclein (SNCA ) and leucine-rich repeat kinase 2 (LRRK2 ). This journal has an h-index of 53. of nuclear paraspeckles, thus regulating transcription and modifying protein functions. impact score may rise in 2022 as well. Objective: Describe and explain the connection between a Helicobacter pylori infection of the upper gut and changes in pharmacokinetics of oral levodopa treatment in Parkinsons disease. But a memorandum from a lawyer advising Syngenta suggests that the work was not independent. -, Casals J, Elizan TS, Yahr MD (1998) Postencephalitic parkinsonisma review. Read the winning articles. npj Parkinson's Disease A common feature of implicated viruses appears to be production of high levels of cytokines and chemokines that can cross the blood-brain barrier leading to microglial activation and inflammation and ultimately neuronal cell death. Parkinson's disease (PD) is a common chronic neurodegenerative disease that places an enormous material and mental burden on patients (1, 2).Although PD is characterized by motor symptoms, a broad spectrum of non-motor symptoms (NMS), including sleep disturbance, neuropsychiatric symptoms, and autonomic dysfunction, can be identified in people with PD (). On the other hand, few consider the only manuscripts sent for peer review or few even not bother about the accurate maintenance of total submissions. Bacterial, viral, and fungal infection-related risk of Parkinson's disease: Meta-analysis of cohort and case-control studies. Article 11 May 2023 Featured The genetic spectrum of a cohort of patients clinically diagnosed as Parkinson's disease in mainland China Yi-Min Sun Xin-Yue Zhou Jian Wang Article Open Access 17. If you need to make more complex queries, use the tips below to guide you. From 2023 the journal will proceed as an open access publication, where all articles from the 2023 volume onwards will be openly available. PublicationFrom 2022, the journal publishes eight issues per annual volume; prior to this it was four issues per year. Although much research has focused on the genetic causes of PD, environmental risk factors also play a crucial role in the development of the disease. The publication country of this journal is Netherlands. Parkinsonism Relat Disord 16, 566571. these concerns, based on our interpretation of the literature plus the unfolding experience with widespread vaccination in the population at large. Huynh VA, Takala TM, Murros KE, Diwedi B, Saris PEJ. Background: Infection with Helicobacter pylori seems overrepresented in Parkinsons disease. Please enable it to take advantage of the complete set of features! Among them, NEAT1 has attracted particular interest. It is increased by a factor of around 0.23, and the percentage change is 4.98% compared to the preceding year 2020, indicating a rising trend. Wolff was giving us guidance on how to communicate, the scientist Philip Botham said in his deposition. MeSH Though PSP is generally regarded as sporadic, there is increasing evidence suggesting that a series of common and rare genetic variants impact on sporadic and familial forms of PSP. Instead, the documents show that when Syngenta met with EPA officials in February 2013 to update the agency on its internal research on the potential for paraquat to cause Parkinsons disease, there was no mention of the adverse findings of the Marks studies. J Parkinsons Dis. The evidentiary files are made up of internal memos, emails, draft scientific reports and other records, along with depositions of key witnesses and scientific experts. 31-43, 2021, Authors: Borsche, Max | Pereira, Sandro L. | Klein, Christine | Grnewald, Anne, Abstract: The Journal of Parkinson's Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinsons disease in cooperation with the Journal of Alzheimer's Disease. However, both persons with PD and physicians looking after these individuals have expressed concerns about the vaccines efficacy and safety in the specific context of PD and its symptomatic treatment. 2019;9(s2):S331-S344. The present review focused on genetic studies on PSP and summarized genetic factors of PSP, which may help to elucidate the underlying pathogenesis and provide new perspectives for therapeutic strategies. 11, no. Hence, it can provide a rough estimation only. bacteria in PD risk. However, both persons with PD and physicians looking after these individuals have expressed concerns about the vaccines efficacy and safety in the specific context of PD and its symptomatic treatment. The Parkinson's Foundation, in partnership with Nature Publishing Group (NPG), publishes npj Parkinson's disease, a scientific journal dedicated to highlighting the most important scientific advances in Parkinson's disease (PD).. Modern neuropathological techniques adding to routine immunohistochemistry might take further our knowledge of these diseases beyond protein aggregates and down to their. 2023 Apr 18;20(1):95. doi: 10.1186/s12974-023-02776-z. When asked to comment about the contents of the documents, a Syngenta spokesperson said: We care deeply about the health and wellbeing of farmers and are dedicated to providing them safe and effective products. Targeting Sigma-1 Receptor: A Promising Strategy in the - Springer Moreover, patients harboring alterations in mitochondrial polymerase. Therefore, antibodies targeting extra-. npj Parkinson's Disease - Impact Factor, Overall Ranking, Rating, h Journal Abbreviation: J PARKINSON DIS Journal ISSN: 1877-7171. FOIA Media Ranking in Egypt. Authors Xin Yuan 1 , Ye Tian 1 , Chaoyang Liu 2 . In a follow-up Paraquat Research Program Update presentation to EPA officials in February 2017, Syngenta held to that position. Journal of Parkinsons Disease Impact Factor IF 2022|2021|2020 A tractor sprays pesticide over a green field. All journals are available in print and electronic format. Action notes from that meeting stated Study work should be labelled Work Product Doctrine Material Confidential, and carry the Attorney Client Privilege statement.. Journal of Parkinson's Disease is cited by a total of 1853 articles during the last 3 years (Preceding 2021). Parkinson's disease Thus, in the second part of this review, we discuss therapeutic approaches targeting mitochondrial dysfunction with the aim to prevent or delay neurodegeneration in PD. and JavaScript. There is a growing interest in identifying common traits which lead to the disease. An email from lawyer Jeffrey Wolff in which he expresses concerns about blunt statements in a Syngenta presentation. [emailprotected], For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [emailprotected], Inspirees International (China Office) However, the potential of NEAT1 as a biomarker and as a therapeutic target for PD highly warrants further research to elucidate its exact role in this neurodegenerative disorder. This journal's impact score, h-index, and SJR are 4.85, 53, and 1.311, respectively. Journal Impact. Modern neuropathological techniques adding to routine immunohistochemistry might take further our knowledge of these diseases beyond protein aggregates and down to their Seeking submissions on invasive and non-invasive neuromodulation in movement disorders. The Syngenta scientist Louise Marks did a series of mouse studies between 2003 and 2007 that confirmed the same type of brain impacts from paraquat exposure that outside researchers had found. It is based on Scopus data and can be a little higher or different compared to the impact factor (IF) produced by Journal Citation Report. Bookshelf Before IS 2021 of Journal of Parkinson's Disease is 4.85. Neurotoxicology. Parkinson's disease represents a fast-growing neurodegenerative condition; the rising prevalence worldwide resembles the many characteristics typically observed during a pandemic, except for an infectious cause. The International Standard Serial Number (ISSN) of Journal of Parkinson's Disease is/are as follows: 1877718X, 18777171. In most populations, 3-5% of Parkinson's disease is explained by genetic . The h-index (also known as the Hirsch index or Hirsh index) is a scientometric parameter used to evaluate the scientific impact of the publications and journals. Headquartered in Amsterdam with satellite offices in the USA, Germany and China, IOS Press continues its rapid growth, embracing new technologies for the timely dissemination of information. 107-121, 2021, Authors: Boros, Fanni Annamria | Vcsei, Lszl | Klivnyi, Pter, Abstract: Based on multiple avenues of evidence it appears likely that specific bacterial and particularly viral infections may increase vulnerability to PD. 1 INTRODUCTION. It has been proposed that NEAT1 propagates PD via its interaction with PINK1 and several micro RNAs and by modulating SNCA expression. Parkinson's disease (PD) is a neurodegenerative disease with different motor and nonmotor symptoms. Some caution seems warranted in very frail and terminally ill elderly persons with PD living in long-term care facilities. Additionally, MAPT mutations are the most common cause of familial PSP while the leucine-rich repeat kinase 2 (LRRK2 ) is a rare monogenic cause of PSP, and several other gene mutations may mimic the PSP phenotype, like the dynactin subunit 1 (DCTN1 ). vol. Search About Journals, Conferences, and Book Series. eCollection 2023. The presentation to the EPA was not geared to the Dr Marks studies, Dixon said in the deposition. Wolff then became more deeply involved, records show. Parkinson's Dis.') If the same upward trend persists, doi: 10.1002/brb3.1549. Journal of Parkinson's Disease is a journal published by IOS Press BV. The publisher of Journal of Parkinson's Disease is IOS Press BV. Based on clinical and prodromal criteria, various PD subtypes have been identified (Poewe et al., 2017).Genetic risk factors impact around 15% of PD patients (Berg et al., 2021) and at least 23 variants have been identified, the most common ones located in Leucine-rich repeat . The Journal of Parkinson's Disease is ranked 2649 among 27339 Journals, Conferences, and Book Series. 123-138, 2021, IOS Press, Inc. JPD has a Journal Impact Factor of 5.520, a 5-Year Impact Factor of 6.135, and a Journal Citation Indicator of 0.90 (2021 Journal Citation Reports, source: Clarivate, 2022). The lawyer pushed scientists to alter problematic language and scientific conclusions deemed unhelpful to the corporate defense of paraquat. To achieve that goal, the company set several objectives, including attempting to influence future work by external researchers where possible. To obtain The acceptance rate/percentage of any academic journal/conference depends upon many parameters. PMC Additional evidence for mitochondrial dysfunction stems from models of autosomal-dominant PD due to mutations in alpha-synuclein (SNCA ) and leucine-rich repeat kinase 2 (LRRK2 ). Parkinson's Disease / For authors On this page For authors For authors Publish with Hindawi Join our community of authors and benefit from: An easy-to-use manuscript submission system, without manuscript formatting requirements. It has been proposed that NEAT1 propagates PD via its interaction with PINK1 and several micro RNAs and by modulating SNCA expression. As per SJR, this journal is ranked 1.311. vol. The ISSN (Online) of Journal of Parkinson's Disease is 1877-718X . Many of the documents cited in this story come from an expert report authored by David Michaels, an occupational health expert and a former top health official in both the Clinton and Obama administrations. Would you like email updates of new search results? Abstracted/Indexed inChemical Abstracts Service (CAS), Embase, Journal Citation Reports/Science Edition, MEDLINE, PsycINFO, PubsHub, Science Citation Index-Expanded (SciSearch), Scopus, News & Social MediaView a selection of newsletters that were sent out recently by clicking on the links: 2020: Issue 1; Issue 2; Issue 3; Issue 4; Special Issue; Parkinson Prize 2020, To receive news and JAD updates, sign up via this link: http://tiny.cc/JPDsignup, Find JPD on Facebook at: facebook.com/journalpd, Follow JPD on Twitter at: twitter.com/journal_pd. these concerns, based on our interpretation of the literature plus the unfolding experience with widespread vaccination in the population at large. gamma (POLG ) often exhibit signs of parkinsonism. ABSTRACT. Unable to load your collection due to an error, Unable to load your delegates due to an error. 5- year Impact Factor (2021) - 9.705 Immediacy index - 1.225 Eigenfactor score - 0.00304 Article Influence Score - 2.296 2-year Median - N/A 167 days to first decision for reviewed. In another round of edits to a scientific slide show, Wolff recommended the deletion of a statement that said We can show loss of cells in the substantia nigra pars compacta. ISSN: 1877-7171. . Degenerating neurons contain abnormal aggregates called Lewy bodies, that are predominantly composed of the misfolded and/or mutated alpha-synuclein protein. Parkinsons disease; bacteria; etiology; infection; viruses. Research and Reviews in Parkinsonism - Dove Press A detail from a Syngenta internal document about its Swat team. If your area of research or discipline is related to Neurology (clinical), Cellular and Molecular Neuroscience, etc., It's publishing house is located in Netherlands. Journal of Parkinson's Disease. Post-translational modifications, cellular stress, inflammation and gene mutations are thought to trigger its pathological misfolding and aggregation. Year: Impact Factor (IF) Total Articles: Total . Front Cell Infect Microbiol. and transmitted securely. We do not include trials in which the MCI is specified to be part of a non-AD disease such as MCI of Parkinson's disease. Background: Infection with Helicobacter pylori seems overrepresented in Parkinsons disease. ACM Kolicheski A, Turcano P, Tamvaka N, McLean PJ, Springer W, Savica R, Ross OA. Cerebrospinal fluid (CSF) and positron emission tomography (PET) markers of A and tau have been shown to be reliable for AD diagnosis. 1, pp. Disclaimer. In another example of a company tactic, an outside lawyer hired by Syngenta to work with its scientists was asked to review and suggest edits on internal meeting minutes regarding paraquat safety. Impact FactorJPD has a Journal Impact Factor of 5.520, a 5-Year Impact Factor of 6.135, and a Journal Citation Indicator of 0.90 (2021 Journal Citation Reports, source: Clarivate, 2022). The interplay between environmental and genetic factors in Parkinson's disease susceptibility: the evidence for pesticides. The ISSN is a unique 8-digit identifier for a specific publication like Magazine or Journal. The presentation stated that a series of Syngenta animal studies found no statistically significant effect of [paraquat] on dopaminergic neuronal cell numbers. He said he currently served as chair of a Syngenta ethics committee. Part of a Syngenta communication about labeling study work with confidentiality markings. Keywords: The memo stresses the importance of proactively publishing research studies that discredit the alleged connection between paraquat and Parkinsons disease and cites, in this context, the continuing (Syngenta-sponsored) work by Berry and the other two authors of the 2010 paper. Most recent research even implicated damage-associated molecular patterns released from non-degraded mitochondria in neuroinflammatory processes in PD. Regrettably, this kind of effective legal ghostwriting of scientific reports happens far too often in the chemical industry. 11, no. -, Chen H, Ritz B (2018) The search for environmental causes of Parkinsons disease: Moving forward. Frontiers | Sleep structure and related clinical characteristics in Toxicology. The latest h-index of Journal of Parkinson's Disease is 53. gamma (POLG ) often exhibit signs of parkinsonism. Some of the critical parameters are listed below. It is a major component and the initiator. Journal Self-citation is defined as the number of citation from a journal citing article to articles published by the same journal. Genes identified and/or proposed to be linked to PD encode proteins that fulfill diverse roles in cellular functions. FOIA Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901 In one key edit, Wolff suggested deleting a statement that read: The combination of experimental data and epidemiological data provides plausibility to the claim that PQ [paraquat] is implicated in PD [Parkinsons disease]., Wolff also took issue with a statement that said only a small percentage of Parkinsons cases were genetic, with the majority resulting from gene-environment or environmental causes. Not every article in a journal is considered primary research and therefore "citable", this chart shows the ratio of a journal's articles including substantial research (research articles, conference papers and reviews) in three year windows vs. those documents other than research articles, reviews and conference papers. Environmental factors in Parkinson's disease: New insights into the Initially originating from the observation that mitochondrial toxins cause PD, findings from genetic PD supported a contribution of mitochondrial dysfunction to the disease. Environmental factors in Parkinson's disease: New insights into the molecular mechanisms. Careers. In the face of the developing research, the new documents show, Syngenta decided that it needed a coherent strategy across all disciplines focusing on external influencing, that proactively diffuses the potential threats that we face, according to the minutes of a June 2003 company meeting. ISO 4 (International Organization for Standardization 4) is an international standard that defines a uniform and consistent system for abbreviating serial publication titles and journals. Wolff suggested, instead, that the presentation say The great majority of PD cases are idiopathic or of unknown cause.. 2022 www.resurchify.com All Rights Reserved. This finding is judged to be real, to be related to treatment and to be adverse in nature. When it is perverted, when it is manipulated, then we get bad results. Clinical observations suggest a suboptimal treatment effect of levodopa in Helicobacter positive patients. An ISSN is an 8-digit code used to identify newspapers, journals, magazines and periodicals of all kinds and on all media-print and electronic. PMID: 33361610 PMCID: PMC7990414 DOI: 10.3233/JPD-202279 Bacterial Infections / complications* Gastrointestinal Microbiome* Humans Parkinson Disease / etiology* Parkinson Disease / immunology* Virus Diseases / complications*